Resumo Este artigo pretende investigar o vínculo entre interdito e transgressão no romance O Nome da Rosa, de Umberto Eco, buscando demonstrar que essa relação se forma através da dependência. Busca, ainda, analisar a curiosidade como uma das formas pelas quais a transgressão se manifesta frente aos interditos impostos na ficção de Eco, não como uma forma de negá-los, mas de superá-los, potencializando-os. Entende-se que a curiosidade como transgressão é resultado de um primeiro interdito, aquele do riso, sendo analisada tanto quando curiositas quando studiositas. Ainda, compreende-se tais manifestações como excesso, um excesso que leva à morte, ressaltando o seu perigo para o mundo homogêneo. O aporte teórico que embasa este artigo é constituído principalmente pela obra de Georges Bataille, com o apoio de Alberto Manguel e Georges Minois. Rosa Eco dependência Busca ainda negálos, negálos negá los, los negá-los superálos, superálos superá superá-los potencializandoos. potencializandoos potencializando os. os potencializando-os Entendese Entende riso studiositas Ainda compreendese compreende morte homogêneo Bataille Minois

Resumen Este artículo pretende investigar el vínculo entre interdicción y transgresión en la novela El Nombre de la Rosa, de Umberto Eco, buscando demostrar que tal relación se da por medio de la dependencia. Busca aún analizar la curiosidad como una forma a través de la cual la transgresión se manifiesta frente a las interdicciones impuestas en la ficción de Eco, no como una manera de negarlas, sino de superarlas potencializándolas. Se entiende que la curiosidad como transgresión resulta de una primera interdicción, aquella de la risa, siendo analizada tanto como curiositas cuanto studiositas. Se comprende, aún, la curiosidad como exceso, un exceso que lleva a la muerte, resaltando su peligro para el mundo homogéneo. El aporte teórico que basa este artículo es constituido principalmente por la obra de Georges Bataille, con el apoyo de Alberto Manguel y Georges Minois. Rosa Eco dependencia negarlas potencializándolas risa studiositas comprende muerte homogéneo Bataille Minois

Abstract This article aims to investigate the relationship between interdiction and transgression in Umberto Eco’s novel The Name of the Rose, aiming to demonstrate that this link is formed through dependence. The paper also seeks to analyze curiosity as one of the channels through which transgression manifests itself in the face of the bans imposed on Eco's fiction, not as a way of denying them, but of overcoming them by enhancing them. It is understood that curiosity as a transgression is the result of a first interdiction, that of laughter, and it is evaluated as both curiositas and studiositas. This expression is considered, also, as excess, an excess that leads to death and destruction, highlighting the danger to the homogeneous world. The theoretical basis of this article is mainly composed of the works of Georges Bataille, with the support of Alberto Manguel and Georges Minois. Ecos Eco s Rose dependence fiction laughter studiositas considered destruction world Bataille Minois

Abstract Objective: This study aimed to analyze the effect of major depressive disorder (MDD) as a risk factor for suicidal ideation in individuals whose ages varied from 11 to 24 years and who were attending educational institutions. Data source: A systematic review was carried out by searching in PubMed and Biblioteca Virtual em Saúde (BVS). Original studies conducted in educational institutions, including individuals whose age varied from 11 to 24 years, in English, Spanish, or Portuguese were included. Data synthesis: Eight studies were selected for the meta-analysis, including 35,443 youths, with an average age of 16.8 years, predominantly female (51.2%), and from middle-income Asian countries (91.6%). An odds ratio of MDD of 3.89 (95%CI 2.46–6.17) for suicide ideation in youth was found. Subgroup analysis showed higher effects in Asia (OR=4.71; 95%CI 3.22–6.89) than Americas (OR=1.71; 95%CI 1.44–2.03). The meta-regression model indicated that younger adolescents (coef=-0.63; 95%CI 1.09–-0.18; p<0.01) and older studies (coef=-0.23; 95%CI 0.039–-0.08; p<0.01) presented higher effects of MDD on suicidal ideation. Conclusions: Early detection and treatment of MDD in youth patients are of utmost importance for preventing suicidal ideation. Educational institutions could play an important role in the early detection and intervention.

Resumo Objetivo: Analisar o efeito do transtorno depressivo maior (TDM) como fator de risco para a ideação suicida em indivíduos com idades entre 11 e 24 anos que frequentam instituições de ensino. Fontes de dados: Revisão sistemática realizada até agosto de 2020 por meio de buscas nas bases United States National Library of Medicine (PubMed) e Biblioteca Virtual em Saúde (BVS), sem limitações quanto à data de publicação. Síntese dos dados: Oito estudos foram selecionados para a metanálise, incluindo 35.443 jovens com idade média de 16,8 anos, predominantemente do sexo feminino (51,2%) e de países asiáticos de renda média (91,6%). Foi encontrado odds ratio (OR) de TDM de 3,89 (intervalo de confiança — IC95% 2,46–6,17) para a ideação suicida em jovens. A análise de subgrupo mostrou efeitos maiores na Ásia (OR=4,71; IC95% 3,22–6,89) do que nas Américas (OR=1,71; IC95% 1,44–2,03). O modelo de metarregressão demonstrou que adolescentes mais jovens (coef=-0,63; IC95% -1,09–-0,18; p＜0,01) e estudos mais antigos (coef=-0,23; IC95% -0,039–-0,08; p＜0,01) apresentaram maiores efeitos do TDM sobre a ideação suicida. Conclusões: Observou-se relação entre TDM e ideação suicida no continente asiático, entre adolescentes mais jovens e em estudos mais antigos.

Abstract The year 2019 brought three such impacts of high socio-environmental proportions in Brazil: the dam collapse in Brumadinho, oil spills on the coast, and fires in the Amazon. We investigated the Brazilian population’s perceptions of the country’s overall environmental situation, the degree to which Brazilians felt affected by these impacts considering personal and social factors, and the entities they held responsible for these disasters. Through Facebook’s social media networks, we disseminated structured online surveys for Brazilian citizens above 18 years. Educational background explained how much the 775 respondents felt affected by the three evaluated events. Age was an explanatory factor for the degree to which the respondents felt affected by the dam collapse, and proximity to the disasters, while income levels were for the dam collapse and the fires in the Amazon. The government, criminal activity, and private companies were considered to be the main responsible for these three impacts. This perception reflects the series of changes in the country’s environmental laws and protections that threaten biodiversity and the environment.

ABSTRACT OBJECTIVE To show the implementation process of IPT-G in primary care, including facilitating and obstructing factors, implementation strategies, and training and supervision of primary care professionals. METHODS Quantitative (cross-sectional and longitudinal) analysis of pre and post-knowledge tests; qualitative analyses of the training courses; patient recruitment; conduction of IPT-G sessions; supervision of IPT-G therapists; application of a semi-structured questionnaire to assess, investigate, and develop strategies against the identified barriers. RESULTS About 120 clinicians answered the pre-test; 84 completed the post-test. Pre- and post-test scores of IPT-G knowledge were significantly different. Twenty initially trained clinicians completed additional supervision in IPT-G. Qualitative analysis identified twelve barriers and six facilitators to IPT-G implementation in individual, organizational, and systemic contexts. CONCLUSIONS Implementation of IPT-G in primary care is a complex process with several steps. In the first step, health professionals were successfully trained in IPT-G. However, subsequent steps were more complex. Therefore, careful planning of IPT-G implementation is essential to maximize the success of this innovation.

ABSTRACT Objective To investigate the histological influence of waterpipe smoke exposure on lung tissues of Swiss mice during the periods of 7, 15, 30, 60, and 90 days. Methods The sample consisted of 60 animals, divided into 6 groups, one control group, exposed only to air, and the other experimental groups, daily submitted to water pipe smoke for 30 minutes through the whole body system, for 7, 15, 30, 60 and 90 days. After these periods, the mice were euthanized to obtain the tissue samples and subsequent preparation and analysis of histological slides. Results In the slide microscopy, the control group presented normal aspects. In experimental groups, exacerbation of inflammation was observed, there was a increased thickness of intra-alveolar septa, reduced alveolar lumen, areas of ciliary loss, and neovascular formation. And as the animals' exposure to smoke was extended, the progressive exacerbation of these pulmonary changes was noted. Conclusions The exposure to waterpipe smoke stimulates inflammation and cellular changes in lung tissues of Swiss mice and suggests that the longer the animals' exposure period, the more exacerbated this picture will appear.

Abstract Objective: The association between diabetes and Strongyloides infection remains controversial. This study aimed to detect Strongyloides stercoralis DNA in the feces of patients with Diabetes Mellitus type 2 (DM2). Methods: Fecal samples were analyzed via the Lutz, Rugai, and agar plate culture methods. PCR amplification was performed using two targets (PCR-genus and PCR-species) located on the S. stercoralis 18S ribosomal. Results: The positivity for S. stercoralis using parasitological methods was 1.1%. PCR-genus (14.13%) demonstrated a higher positivity than PCR-species (9.78%). Conclusion: The results confirm the greater positivity of the molecular diagnosis in relation to parasitological methods, reinforcing its use as an additional tool for the diagnosis of S. stercoralis infection in patients with DM2 living in endemic areas for this helminthiasis. HIGHLIGHTS Positivity for strongyloidiasis in coproscopic exam was low in diabetic patients. PCR is more sensitive for detecting S. stercoralis infection in diabetic patients. Molecular diagnosis is an important tool for the detection of S. stercoralis.

ABSTRACT OBJECTIVE To show the implementation process of IPT-G in primary care, including facilitating and obstructing factors, implementation strategies, and training and supervision of primary care professionals. METHODS Quantitative (cross-sectional and longitudinal) analysis of pre and post-knowledge tests; qualitative analyses of the training courses; patient recruitment; conduction of IPT-G sessions; supervision of IPT-G therapists; application of a semi-structured questionnaire to assess, investigate, and develop strategies against the identified barriers. RESULTS About 120 clinicians answered the pre-test; 84 completed the post-test. Pre- and post-test scores of IPT-G knowledge were significantly different. Twenty initially trained clinicians completed additional supervision in IPT-G. Qualitative analysis identified twelve barriers and six facilitators to IPT-G implementation in individual, organizational, and systemic contexts. CONCLUSIONS Implementation of IPT-G in primary care is a complex process with several steps. In the first step, health professionals were successfully trained in IPT-G. However, subsequent steps were more complex. Therefore, careful planning of IPT-G implementation is essential to maximize the success of this innovation.

ABSTRACT Blastocystis sp. is an enteric protist commonly found in human fecal samples. In Brazil, few studies have been developed, but none of them has explored the presence of Blastocystis in patients with diabetes mellitus. We evaluated the occurrence and molecular identification of Blastocystis sp. among patients with diabetes mellitus in the Midwest region, Goias State, Brazil. Genomic DNA was obtained from 175 fecal samples (99 from the diabetic group and 76 from the control group). PCR was performed using pan-Blastocystis primers from the SSU-rDNA gene. Microscopic examination revealed positivity of 12.1% and 7.9% for Blastocystis in diabetics and in controls, respectively. Amplification of Blastocystis DNA was observed in 34.4% (34 of 99) and 30.3% (23 of 76) from the diabetic and control groups, respectively. Phylogenetic analyses and BLAST searches revealed six subtypes among Blastocystis isolates in the diabetic group, represented by ST1 (38.2%), ST2 (11.8%), ST3 (35.3%), ST6 (2.9%), ST7 (2.9%) and ST8 (8.8%). In the control group, ST1 (21.8%), ST2 (21.8%), ST3 (43.5%), ST6 (4.4%) and ST8 (8.7%) were identified. This study is the first report regarding the occurrence and subtypes distribution of Blastocystis in patients with diabetes mellitus in Brazil. The results reinforce the potential risk of Blastocystis infection in patients with diabetes, in addition, it contributes to the understanding of the genetic diversity of this enigmatic organism.

Abstract A new oleic acid derivative plasticizer, epoxidized trimethylolpropane trioleate (EPO), has been synthesized and its application in PVC formulations compared with di(2-ethylhexyl) 1,2-cyclohexanoate (DOCH/DEHCH), a commercial phthalate-free plasticizer of petrochemical origin. EPO and their blends with DOCH were added to PVC resin (50 PHR) and the plasticized PVC has been characterized by thermal and mechanical measurements. EPO demonstrated good compatibility with the PVC resin improving the thermal stability and elongation at break. Due to EPO high molar mass, a slight increase in the glass transition temperature and hardness was observed as the content of EPO in the plasticizer blend increased. The results indicate that EPO is a potential plasticizer for PVC when pure and, by replacing 50% of DOCH, the PVC compound shows similar properties to pure DOCH, but better elongation at break and thermal stability.

RESUMO Objetivo Estratégias para preparar a criança com atividades lúdicas, a fim de estabelecer uma relação amigável inicial entre paciente e dentista, são amplamente utilizadas como um meio de amenizar comportamentos inconsistentes e emoções negativas durante o tratamento odontológico. Assim, os objetivos deste estudo foram avaliar as emoções das crianças antes e depois de realizar atividades lúdicas e ao final do tratamento odontológico, bem como avaliar o comportamento infantil. Methods Participaram deste estudo 74 crianças, meninos e meninas, com idades entre 4 e 10 anos, que frequentaram a Clínica de Odontopediatria por dois semestres consecutivos. As crianças responderam como se sentiram através do deck de emoções durante as três etapas. Além disso, dados sobre comportamento e procedimentos também foram coletados. Results Foram avaliadas 468 emoções, das quais 69 (14,75%) foram negativas e 399 (85,25%) foram positivas; a alegria foi a de maior frequência nos três momentos avaliados. Foram observadas 128 (82,05%) emoções positivas antes, 133 (85,25%) após as atividades lúdicas e 136 (87,18%) das emoções positivas após o tratamento odontológico. Quanto às emoções negativas, 28 (17,94%) eram anteriores, 23 (14,74%) após atividades lúdicas e 20 (12,82%) após tratamento. Em relação ao comportamento, apenas 9 (5,77%) não foram registrados como cooperativos, enquanto 147 colaboraram (94,23%). Conclusion Portanto, foi possível concluir que a maioria dos pacientes apresentou emoções positivas nos diferentes momentos avaliados e as emoções negativas foram observadas principalmente antes das atividades lúdicas, apresentando redução após o atendimento odontológico. A maioria dos pacientes demonstrou comportamento cooperativo.

ABSTRACT Objective Strategies to prepare the child with play activities in order to establish an initial friendly relationship between patient and dentist are widely used as a means to soften the inconsistent behaviors and negative emotions during dental treatment. Thus, the objectives of this study were to evaluate the emotions of children before and after performing play activities and at the end of dental treatment, as well as assessing child behavior. Methods A total of 74 children, both boys and girls, aged 4 to 10 years old, participated in this study and attended the Pediatric Dentistry Clinic for two consecutive semesters. The children responded as they felt through the Emotions Deck during the three stages. In addition, data on behavior and procedures were also collected. Results A total of 468 emotions were evaluated, of which 69 (14.75%) were negative and 399 (85.25%) were positive; the joy was the one of greater frequency in the three evaluated moments. A total of 128 (82.05%) positive emotions were observed before, 133 (85.25%) after the play activities and 136 (87.18%) of the positive emotions were after the dental treatment. As for negative emotions, 28 (17.94%) were before, 23 (14.74%) after play activities and 20 (12.82%) after treatment. Regarding behavior, only 9 (5.77%) were not registered as cooperative, while 147 collaborated (94.23%). Conclusion Therefore, it was possible to conclude that the majority of the patients presented positive emotions at the different moments evaluated and the negative emotions were observed mainly before the ludic activities, having a reduction after the dental care. Most patients demonstrated cooperative behavior.